February 2023

Penicillins and it Effects on Sexually Transmitted Diseases

Penicillin is a metabolic product of the mould penicillium notatum. A structure include a b-lactam ring with four members which gives it the specific potency. As can be seen below, penicillin chemical structure how’s the alterations of the side chain (R), which can lead to formation of many derivative. Chemical structures of penicillin Penicillin mode

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Antimicrobial therapy

Antimicrobial therapy aims at treating infection with a drug to which The casual microorganism is sensitive and which has a selective toxicity only for the infecting organism without harming the Host cells. Some antimicrobials are bacteriostatic, i.e., the arrest multiplications of bacterias, e.g., chloramphenicol, erythromycin and sulphonamides. If the drug is withheld, the organism May

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Antimicrobial drugs of clinical importance

Antimicrobial drugs may be antibiotics, which are produced by living microorganism, or chemical antimicrobial which are synthetic chemical compound. Commonly used Antibiotics Commonly used antibiotics include the penicillin, cephalosporins, aminoglycoside, chloramphenicol, tetracycline, polymixins, in rifampicin, erythromycin, fusidic acid, clindamycin and vancomycin. Griseofulvin and amphotericin antifungal antibiotics. Common Synthetic Antibiotics The common synthetic antimicrobial as a

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Laboratory Tests to Monitor Antimicrobial Therapy

The microbiology laboratory can help to monitor the effectiveness of antimicrobial therapy in two ways: 1. By determining the inhibitory activities of antimicrobial agent on the isolated pathogens. 2. Bye the assessment of patient respond to the antimicrobial therapy. i. Quantitation of the level of the antimicrobial agent in the body fluid especially serum. ii.

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Penicillin Resistance and B-lactamase

Penicillin resistance and B-lactamase B-lactamases are heterogeneous bacterial enzymes which cleave b-lactam ring of penicillins and cephalosporins to inactive the drugs. Many bacterial species are known to produce them. Clinically the most important bill at time is producer are staphylococcus aureus, haemophilus species and Neisseria gonorrheae. The enzyme may be located on the chromosome but

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